DISC-3D: DUAL-HYDROGEL SYSTEM ENHANCES OPTICAL IMAGING AND ENABLES CORRELATIVE MASS SPECTROMETRY IMAGING OF INVADING MULTICELLULAR TUMOR SPHEROIDS

Abstract Multicellular tumor spheroids embedded in collagen I matrices are common in vitro systems for the study of solid tumors that reflect the physiological environment and complexities of the in vivo environment.While collagen I environments are physiologically relevant and permissive of cell invasion, studying spheroids in such hydrogels prese

The Artificial Bee Colony (ABC) algorithm is ALMOND MEAL a bionic intelligent optimization method.The cloud model is a kind of uncertainty conversion model between a qualitative concept T ˜ that is presented by nature language and its quantitative expression, which integrates probability theory and the fuzzy mathematics.A developed ABC algori